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Screening Kit for Paroxysmal Nocturnal Haemoglobinuria (PNH)

Paroxysmal Nocturnal Haemoglobinuria (PNH) is an acquired hematopoietic stem-cell disorder related to the somatic mutation in PIG-A gene (X-chromosome). This genetic alteration results in partial or total deficiency of all proteins normally linked to the cell membrane by glycosylphosphatidyl-inositol (GPI). Flow cytometry provides an efficient diagnostic test in which the lack of GPI-anchored proteins is studied on the major blood cell populations.

 

PNH Screening Kit is a 4-color reagent used to evaluate the possible loss of expression of two GPI-anchored proteins, CD16 molecule on neutrophils and CD14 molecule on monocytes.

 

PNH Screening Kit includes the following antibody combination:

 

FITC
PE
PerCP-Cyanine5.5
APC
CD16
CD64
CD45
CD14

 

PNH Screening Kit antibody combination can detect the existence of GPI deficiency cells with great sensitivity. Anti-CD45 and anti-CD64 antibodies allow identifying neutrophils and monocytes. Further evaluation of the loss of CD16 and CD14 in these populations allows the identification of the PNH clone in a fast and simple way.

 

PNH Screening Kit                   PNH Screening Kit
PNH Screening Kit PNH Screening Kit
Infinicyt
Abnormal peripheral blood sample stained with PNH Screening kit

 

Description
Size
Catalog code
Status
TDS
PNH Screening Kit
25 tests
CYT-HPN-1
RUO
PDF

 

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