Last version 29/06/2020 Infinicyt 2.0.4

What’s new?
Changelog

Are you looking to improve flow cytometry data quality and analysis efficiency in your laboratory daily activities?

Not all team members have the same experience/knowledge within your laboratory team which can make your laboratory workflow less efficient. Infinicyt™ provides a new revolutionary way to manage clinical data in an accurate and effective manner. Assure a precise selection of all cell populations with multiple hand-free gating and customizable population tree labels. Analysis templates can be prepared according to your laboratory preferences for each disease under study and automatically loaded based on file parameters. Reference databases together with automated tools aid on making your analysis more objective and reproducible between operators.

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Would you like to show the most informative data from your multicolor panels in your analysis and reporting?

Stop struggling on how to display the most relevant information of your complete panel in your analysis diagrams. Classic diagrams can be configured to display seven different visualization displays (e.g. dots, means, medians, SD, etc.) which can be also used to select events. Data from the complete panel can be included in multi-parameter and statistical diagrams. All diagrams and displays can be exported in publication quality or included in Infinicyt™ built-in report. Infinicyt™ also includes an automatic report designed specifically for each disease type which includes alerts regarding sample quality (hemodilution, LOD) and age-reference ranges with relevant comments, conclusions in 13 different languages. Communication between laboratory personnel and clinicians can now be completely standardized.

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Would you like to decrease analysis time and obtain more reliable diagnosis and monitoring?

Avoid redundant gating strategies that reduce the time you can dedicate to interpret each patient data. Optimize the analysis of your multicolor panels to save time. The increasing number of markers and colors used in clinical flow cytometry requires for advanced analysis tools that make easier evaluation of routine samples. Complete panels can be analyzed together with overlaid information in order to gate the populations of interest in all files at the same time. These analysis strategies can be stored and applied to any new patient for a specific clinical flow study. Reference images of pathological or normal populations can be used during patient follow-up to unequivocally identify abnormal patterns. Analysis can be performed automatically in batch using analysis strategies or EuroFlow™ databases (Automatic Gating and Identification) to reduce analysis time.

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Do you need to reinforce your quality procedures and documentation?

Ensuring that your current software version complies with your laboratory quality standards can be troublesome. Cytognos has extensive quality procedures in order to develop Infinicyt™ which ensure that the software generates correct results for all patients. Over 1000 individual tests are performed and results from manual and automatic tests are documented. Before any release, Infinicyt™ undergoes in-house verification and external validation from the EuroFlow™ consortium. Cytognos performs periodic scheduled reviews of all quality procedures and documentation. Ask us for an IQ/OQ program that provides evidence of Infinicyt™ works within the specifications of your flow cytometry data.

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Are you looking to improve security and traceability of your analysis?

Security and traceability of your laboratory data can be one of the most important responsibilities in a laboratory that deals with patient information. Track “who did what and at what time” in your patient files. Files can be anonymized, encrypted and password protected to ensure data security during transmission. Electronic signatures certify analysis and reports. Even if there is an Infinicyt™ crash you can perform an auto-recover of your patient files. For us your patient data is one the most important aspects to take care of so we work that you will never lose relevant information.

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Still wondering what Infinicyt™ can do for you?

Improve laboratory efficiency

  • Save time in analysis and in result interpretation with innovative tools such as the APS diagram, reference images and Automated Gating and Identification tool.
  • Perform reproducible analysis with pre-saved analysis strategies.
  • Create easily and save unlimited and flexible analysis templates.
  • Analyze all tubes of a panel at the same time and integrate all results in a single report.
  • Export all results directly into your laboratory integration system (LIS).

Provide better patient care

  • Integrate information of complete panels for a better evaluation of the pathological cells and the immune context.
  • Use the APS tool to evaluate what are the better marker to be used in your panel design.
  • Perform a better follow up of patient samples along time using reference images of the different evaluation time points.
  • Evaluate MRD with great performance when working with large files.
  • Perform agile gating, visualize all acquired events and use customizable statistics to calculate ratios, limits of detection and quantification.
  • Use the Automated Analysis and Identification tool for a standard comparison of patient files against a robust reference database to obtain a highly reliable analysis and interpretation.

What do the experts say?

Cytognos is developing Infinicyt™ for more than 13 years in a clinical setting. More than 2000 users have already included it in their laboratory routine.

“I still remember how the introduction of the Infinicyt software revolutionized the way we analyzed flow data in our laboratory. Over the years, I had the opportunity to share our experience with many clinical cytometrist around the world, and it was remarkable to see that everywhere we went they felt exactly the same we did: a perfect balance between the most sophisticated software tools for advanced analysis of flow data in a user-friendly and fast software.”

Bruno Paiva, PhD Director of the Flow Cytometry Unit, CIMA, University of Navarra Pamplona, Spain

“I have been an Infinicyt™ user since 2009 and I find it a very helpful software to screen for and analyze files of hematological malignancies. I like the idea of not using prefixed templates or quadrants and be able to perform a fast, sequential analysis to identify and characterize each cellular population. It has some features that I particularly enjoy, namely the Automated Population Separator (APS) which provides a n-dimensional separation of events based on all the parameters in the file. This feature has proved very advantageous in complex samples like bone marrow aspirates or when a detailed analysis of a large number of events is required to identify a cluster of cells, as in rare event analysis, e.g. MRD samples. The maturation tool opens new insights in evaluating the maturation patterns of different lineages based on different markers and is very relevant when there is a clinical suspicion of MDS. Finally, the use of the compass tool enables new automated classification based on databases of normal samples or comprehensively pre-diagnosed cases of different clonal entities.”

Maria Arroz, MD Director of the Flow Cytometry Laboratory, CHLO, Hospital S. Francisco Xavier Lisbon, Portugal

“As a clinical flow cytometry lab that does leukemia testing and monitoring during treatment,the Infinicyt program has opened up a new window for us in minimal residual disease analysis, as well as routine flow analysis. The APS is an amazing tool, and has enabled us to monitor our patients, in a way that routine programs cannot. The technical support and training are great. Any question or problem we have is promptly solved.”

Ellen Broide, Lab Supervisor Flow Cytometry Unit, Dept. of Immunolgy Jerusalem, Israel

“(…) Thorough all the software I have used I have never had one to be so simple and intuitive to use. The flexibility of the Infinicyt process to identify populations makes the analysis less tedious than most other software. (…) The software gives us confidence to clearly identify populations at the LOD in MRD cases that our previous analysis software could not do. Extras like the APS algorithm, maturation sequences, merging files and creating “normal reference” libraries as well as a personal abnormal file for each patient for post treatment comparisons really puts this software way above all others (…)”

Becky B. Owens MT (ASCP), Supervisor Clinical Flow Cytometry, University of Arkansas for Medical Sciences, Little Rock, Arkansas USA

The Infinicyt software is intuitive and permits easy establishment of analysis panels and protocols. In single tubes it permits isolation and characterization of small subpopulations. In addition, the ability to merge files which contain an adequate backbone enhances the utility of flow cytometry in the diagnosis and classification of both leukaemias and lymphomas as the cell surface profile can be clearly determined. It is invaluable in the analysis of myelodysplasias for definition of aberrant antigen expression and assessment of the maturation profiles; in analysis of leukaemias at diagnosis, relapse and in the evaluation of MRD, where aberrant antigen expression and population overlay may impede conventional analysis strategies. As a clinical haematologist responsible for the flow cytometry section of a large clinical laboratory, I find Infinicyt an invaluable desktop software for rapid analysis and verification of the complex blood, node and marrow samples that I review on a daily basis.

Dr Elizabeth Bernal, Deputy Director Haematology, Douglass Hanly Moir Pathology, Sidney, Australia

Infinicyt™ is by far the most stable and flexible software product for data analysis in flow cytometry that I use. The Infinicyt™ has an easy-to-use interface with a single query field and the possibility to select between several data sources. In my laboratory the Infinicyt™ software is used both for routine diagnosis and research purposes. The innovative features of Infinicyt™ are: is user-friendly, intuitive software allowing a wide range of analytical possibilities, and is first tool that allow constructing a database that improve the classification and comparison of data with implications in disease monitoring through and beyond treatment. Moreover, the Cytognos’ team has excellent communication skills and provides fast response and turnaround time for any possible problem.

Pr. Lydia Campos, Head Laboratory Hematologist and Dr. Carmen Aanei, Hematologist, Centre Hospitalier Universitaire de Saint Etienne, Saint Etienne, France

“It was definitely an eye-opening experience when I began to use Infinicyt software. Multidimensional analysis and many innovative features such as cluster of events and APS are really helpful for distinguishing pathologic and normal populations of hematological diseases. The software provides objective data processing and a user-friendly interface also makes sure of the quality, accuracy and feasibility of results, especially for the minimal residual disease detection. Besides, technical support for any question gets solved in short time.”

Shao-Min Han, Physician. Tai Chen Cell Therapy Center, Taipei, Taiwan

“My first analysis program was paint-a-gate, from there we made the leap to Infinicyt 12 years ago and the change has been amazing. It is a program for cytometrists made by cytometrists. Its original tools such as batch analysis, APS, compass, reference images, maturation patterns, etc. make it the most complete software for my studies.”

Dr. Evan Jensen Gamboa, Flow Cytometry Specialist, Hospital Nacional de Niños Carlos Sáenz Herrera, San Jose, Costa Rica

“We have been using Infinicyt software for over two years at our institution, particularly for MRD applications. The software includes many innovative and advanced tools for analysis of flow cytometry data. It can handle huge MRD files produced by collecting over 10 million events efficiently and fast. Features such as ability to merge multiple files, and analysis based on Automatic Population Separator (APS) are extremely helpful in analysis of data, particularly identifying very small populations at 0.001 to 0.0001% levels. One of the best features of the software is the capability to display all the events collected together in open gates without compromising the ability of the analyst to recognize a tiny subpopulation of interest. As a user, if it happens that you need help, knowledgeable staff at Cytognos are always there to help.”

Dr. Franklin Sedarat, Qsquared (USA)

Resources

Academy

EuroFlow™ Databases