Screening Kit for Paroxysmal Nocturnal Haemoglobinuria (PNH)
Paroxysmal Nocturnal Haemoglobinuria (PNH) is an acquired hematopoietic stem-cell disorder related to the somatic mutation in PIG-A gene (X-chromosome). This genetic alteration results in partial or total deficiency of all proteins normally linked to the cell membrane by glycosylphosphatidyl-inositol (GPI). Flow cytometry provides an efficient diagnostic test in which the lack of GPI-anchored proteins is studied on the major blood cell populations.
PNH Screening Kit is a 4-color reagent used to evaluate the possible loss of expression of two GPI-anchored proteins, CD16 molecule on neutrophils and CD14 molecule on monocytes.
PNH Screening Kit includes the following antibody combination:
FITC |
PE |
PerCP-Cyanine5.5 |
APC |
CD16 |
CD64 |
CD45 |
CD14 |
PNH Screening Kit antibody combination can detect the existence of GPI deficiency cells with great sensitivity. Anti-CD45 and anti-CD64 antibodies allow identifying neutrophils and monocytes. Further evaluation of the loss of CD16 and CD14 in these populations allows the identification of the PNH clone in a fast and simple way.
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Abnormal peripheral blood sample stained with PNH Screening kit |
Description |
Size |
Catalog code |
Status |
TDS |
PNH Screening Kit |
25 tests |
CYT-HPN-1 |
RUO |
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